I hope to do quite a few papers on this subject. In general there is no such thing as transsexualism and there is no such thing as transsexuals. Nobody is born in the wrong body.
~10% of transsexuals, mostly gay transwomen, do have a female-shifted brain, but it is not an actual female brain. Their brain is simply in between a male and female brain, so it is female-shifted if you will. But there is no one who is stuck in the wrong body. No one has a female brain in a male body or vice versa.
And a recent flood of new cases, mostly in teenage girls, is simply a mental illness being caused by social contagion. In this sense it is quite similar to Anorexia Nervosa and in fact, these girls resemble anorexics in many ways. All of this is completely fake. None is real at all.
I have to have some sympathy for some transsexuals, mostly gay transwomen. These boys have stubbornly insisted that they were girls from an early age such as two or three. Such cases are intransigent and resistant to treatment. I am just fine with transition for these folks.
The rest are just mostly very effeminate gay men who are so effeminate that they think they are women, sort of an extreme form of homosexuality.
Many transmen are simply very butch lesbians. Whereas in the past they would simply have identified as lesbians and lived their lives this way (something I am just fine with in these cases as I feel it is biological), now they are insisting that they are really men and transitioning. As might be expected a lot of lesbians are pretty mad about this. They hate men enough anyway, and now many of the recent crop of lesbians are insisting that they are the hated gender. Oh noes!
Puberty blockers are catastrophic and they are being given out en masse to very young children nowadays. The results are disastrous and I think this should be done seldom if ever.
Risks of puberty blockers: Sterility and permanent loss of sexual function. Very high levels of sterility. Impairment of bone mineralization, hence weak bones that easily break. Impairment of proper hip development (females only). Results in a male hip instead of a proper hourglass shaped female hip.
Risks cross-sex hormones for MtF only: 5X rate of throboembolic disease. The estrogen causes blood clots in these men’s veins, how I have no idea. Gynecomastia, rarely reversible. These men develop female-type breasts or moobs that never go away.
Risks of cross-sex hormones for FtM only: Hirsutism, very difficult to reverse. They will have hairy bodies for the rest of their lives even is they detransition. For instance, even if these women go back to being women, they will still have to shave their faces for the rest of their lives. Deeper voice – this is permanent.
Risks of cross-sex hormones only: Elevated heart attack rate, possibly in both sexes.
Transition unnecessary in childhood – no need for immediate transition to prevent suicide: No evidence that transition with drugs and surgery before adulthood reduces the trans suicide rate.
Fake disorder – transsexualism is not real – they are all just mentally ill: Rates of mental disorder and autism among FtM transsexuals are very high, mostly Borderline Personality Disorder and autism.
Unnecessary – goes away on its own: 80% of childhood onset gender dysphoria resolves, often with puberty.